EndoPAT (endothelial function testing)
A non-invasive fingertip test measuring blood-vessel responsiveness, used as an early marker of vascular and cardiometabolic health before symptoms appear.
What it is & how it works
A non-invasive test using fingertip probes to measure changes in arterial pulse volume in response to temporary blood-flow occlusion (reactive hyperemia), producing a reactive hyperemia index that reflects endothelial — blood vessel lining — function, an early marker of vascular health that can be altered before other cardiovascular risk factors become apparent.
How it's done
A roughly 15–20 minute test performed with fingertip probes on both hands while seated; a blood-pressure cuff briefly occludes flow to one arm for about 5 minutes before release, and the resulting pulse-wave response is recorded and analyzed by software, then reviewed by a physician alongside other cardiometabolic diagnostics.
Why Unfold Longevity
Used alongside standard cardiometabolic diagnostics to add an early, functional marker of vascular health, interpreted by a physician as part of an individualized risk assessment rather than a stand-alone score — consistent with Unfold Longevity's evidence-bounded, diagnostics-first approach.
An adjunct marker of vascular function, not a stand-alone diagnostic for cardiovascular disease; interpreted alongside standard risk factors and other diagnostics. Non-invasive, no known risk beyond brief cuff-related discomfort.
Related questions
It measures how well the blood vessel lining (endothelium) responds and dilates after a brief period of restricted blood flow, a functional marker of vascular health that can change before blood pressure, cholesterol, or other standard risk factors show a problem. It's used as an early, adjunct marker rather than a stand-alone diagnosis.
The cuff inflation causes brief, temporary discomfort in the arm for the roughly 5-minute occlusion period, similar to a standard blood-pressure reading held longer than usual, and resolves immediately on release. The test itself takes about 15–20 minutes total.
Every treatment starts with a proper assessment
Not treatment sold on the first call. A clinician reviews your case before anything is recommended.